Novel Affibody Molecules Specifically Bind to SARS-CoV-2 Spike Protein and Efficiently Neutralize Delta and Omicron VariantsArticle Published on 2023-02-142023-07-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), [키워드] affibody FP fusion peptide neutralization RBM receptor binding motif S protein SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2. SPR [DOI] 10.1128/spectrum.03562-22 PMC 바로가기
Design of immunogens for eliciting antibody responses that may protect against SARS-CoV-2 variantsArticle Published on 2022-09-262022-11-15 Journal: PLoS Computational Biology [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding Affinity maturation analysis Analysis antibody Antibody Response Antigen antigens caused cleavage site Combination coronavirus coronavirus determine Evolution fusion peptide immunization immunogen Infection Mutation outbreak predict promote PROTECT RBD expression SARS-CoV-2 variant sequence spike Strains Structure targets the antibody response Vaccine variant variants virus wildtype zoonotic coronavirus [DOI] 10.1371/journal.pcbi.1010563 PMC 바로가기
SARS-CoV-2 variants and spike mutations involved in second wave of COVID-19 pandemic in IndiaArticle Published on 2022-09-012022-11-15 Journal: Transboundary and emerging diseases [Category] SARS, 변종, 진단, 치료기술, [키워드] Against Alpha Amino acid analysed Analysis B.1.1.7 B.1.617.2 biological significance carried circulating circulation country COVID-19 COVID-19 pandemic COVID-19 second wave Critical cytoplasmic domain domains dominant lineage fusion peptide GISAID help India involved Kashmir Lineage Local MONITOR Mutation mutations N-terminal domain National Neutralizing antibodies pathogenicity Prevalence Protein Receptor binding domain regimen reported S protein SARS-CoV-2 SARS-CoV-2 genomic sequence SARS-CoV-2 variant second wave signal peptide spike mutation Spike protein Spike protein variants the S protein transmembrane region Vaccine vaccine breakthrough infections variant viral mutation virus were recorded whole-genome Whole-genome sequence whole-genome. [DOI] 10.1111/tbed.14508 PMC 바로가기
Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 ProteaseArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] SARS, 변종, 치료기술, [키워드] 229E Activation acute respiratory syndrome affected airway being benefit Calu-3 cell change changes in cleavage conserved coronavirus creating Critical Delta dibasic experiment favor functional fusion peptide had no help host cell human coronavirus 229E humans immune evasion immunogenic Impact influence less MERS-CoV Middle East motif mutant Mutation mutations new SARS-CoV-2 no difference omicron pathogenic protease Proteases Protein pseudovirus pseudovirus entry reduced remained residue residues respiratory syndrome coronavirus reverse effect SARS-CoV-2 SARS-CoV-2 spike sequence shown spike spike functioning Spike protein spike protein. Surveillance the SARS-CoV-2 TMPRSS13 TMPRSS13 protease TMPRSS2 Tolerance variant variants Variation virus entry Wuhan-Hu-1 [DOI] 10.1128/mbio.01376-22 PMC 바로가기
ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodiesACE2 결합은 코로나바이러스 항체를 광범위하게 중화시키는 SARS-CoV-2 융합 펩타이드를 노출시킵니다Article Published on 2022-08-122022-09-11 Journal: Science (New York, N.y.) [Category] COVID19(2023년), MERS, SARS, 비임상, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Alpha alpha- analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal coronavirus Animal coronaviruses antibody approach betacoronaviruses binding breadth breath conserved coronavirus coronavirus spike protein donors enzyme epitope functional fusion peptide hidden host receptor Host receptors immune in vitro in vivo mAb mAbs monoclonal antibodies monoclonal antibody motif neutralize Neutralizing Neutralizing activity omicron pathology peptide prefusion recognize reduce respiratory SARS-CoV-2 selected Seven severe acute respiratory syndrome Coronavirus somatic mutations spike glycoprotein Spike proteins the SARS-CoV-2 Viral viral burden virus viruses [DOI] 10.1126/science.abq2679 PMC 바로가기 [Article Type] Article
Broadly neutralizing antibodies target the coronavirus fusion peptide광범위 중화 항체는 코로나바이러스 융합 펩티드를 표적으로 한다Article Published on 2022-08-122022-09-12 Journal: Science (New York, N.y.) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome Alpha antibodies antibody approach arginine residue betacoronaviruses caused cleavage site conserved coronavirus coronavirus vaccine Coronaviruses crystal structure disease epitope fusion peptide helical structure highlight identify include monoclonal antibody neutralize neutralizing antibody omicron outbreak Pathogens Receptor binding SARS-CoV-2 Seven Spike protein the SARS-CoV-2 [DOI] 10.1126/science.abq3773 PMC 바로가기 [Article Type] Article
Spike Mutation Profiles Associated With SARS-CoV-2 Breakthrough Infections in Delta Emerging and Predominant Time Periods in British Columbia, Canada캐나다 브리티시 컬럼비아 주 델타의 신흥 및 우세 기간에 SARS-CoV-2 돌발 감염과 관련된 스파이크 돌연변이 프로필Article Published on 2022-07-042022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] breakthrough infections Canada case-control study Community community setting contribute COVID-19 COVID-19 vaccination Delta domain dose effective epidemiological data estimates Evolution of SARS-CoV-2 fusion peptide genomic group identify individuals information less Logistic regression mechanism Mutation mutations N-terminal domain NTD pandemic penalized regression peptide Period population level Previous studies previous study profile public health measure RBD Receptor binding domain Region regions Relative risk Result risk S1/S2 cleavage SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants second vaccination Sequencing spike spike mutation spike mutations Spike protein stratified Surveillance thought time unique Vaccine Vaccine breakthrough vaccine breakthrough infection vaccine breakthrough infections vaccine escape Vaccine-induced immunity variant variants was used whole genome Whole genome sequencing whole genome sequencing. [DOI] 10.3389/fpubh.2022.915363 PMC 바로가기 [Article Type] Article
Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2 Research Published on 2022-06-302022-10-05 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 animal models antibody Antiviral antivirals bind conserved convalescent patient coronavirus coronavirus COVID-19 epitope functional fusion peptide HCoV-OC43 Infection mechanism membrane fusion murine Neutralizing activity observation outbreak peptide postfusion prefusion Prophylactic reactivity S2’ site SARS-CoV-2 spike trimer target the SARS-CoV-2 the spike protein therapeutic unique Vaccine variants viral entry β-Coronaviruses [DOI] 10.1038/s41564-022-01155-3 [Article Type] Research
Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spikeSARS-CoV-2 Omicron BA.2 스파이크의 Cryo-EM 구조Article Published on 2022-06-282022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody binding antibodies coronavirus CP: Microbiology cryo-EM Cryoelectron microscopy determine domain ectodomain epitope Epitopes functional fusion peptide hallmark immune immune evasion induce Interaction less Lineage Microbiology Microscopy Mutation neutralize omicron Omicron BA.2 Omicron variant peptide proportion Protein Pseudovirus neutralization assay RBD Receptor binding domain receptor binding domain. Region remodeling respiratory resulting S proteins SARS-CoV-2 SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus Structure structures the RBD underlie variant Variation [DOI] 10.1016/j.celrep.2022.111009 PMC 바로가기 [Article Type] Article
ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike ProteinORFeome 파지 디스플레이, SARS-CoV-2 스파이크 단백질의 S2 하위 도메인에 대한 주요 면역원성 에피토프 공개Article Published on 2022-06-172022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Amino acid amino acid sequence anti-SARS-CoV-2 antibodies antibodies antibody Antibody Response Antibody responses applied approved binding binding site blocking cell entry cleave COVID-19 COVID-19 pandemic COVID-19 patients Diseases display Efficacy epitope epitope mapping Epitopes fusion peptide genomic genomic library Host host cell identify immunogenic library Major mechanism monoclonal antibody mutate Mutation neutralization neutralize NGS Open reading frame open reading frames ORFeome ORFs Particle peptide phage phage display. RBD RBD region Receptor binding domain representing SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants sequence Serine serine protease serine protease TMPRSS2 spike the cell the RBD the SARS-CoV-2 genome therapeutic therapy TMPRSS2 Vaccine virus variants [DOI] 10.3390/v14061326 PMC 바로가기 [Article Type] Article